Researchers Use Experimental Drug on Mice And Successfully Reverse Baldness and Skin Damage

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Hair loss has been a huge issue for many people, so you can imagine that many scientists have tried to solve this problem the best way possible. The researchers at Johns Hopkins found a solution which for not it is successful in mice. They findings were published in the journal Scientific Reports.

They used a drug that reversed baldness, whitening of the hair and skin inflammation – all side effects were created by the high-fat diets the mice received.

About the Research

The team looked at a type of fat in the skin and cell membranes – GSLs (short for glycosphingolipids). They reached the conclusion that the GSLs in the skin could help them find a way to treat baldness. They tested to see what happened if they inhibited the activity of GSLs. The team created a molecule named D-PDMP that would inhibit the activity of GSLs and the next phase of the study began.

The researchers engineered a mouse model that had defect in processing fats and cholesterol. They fed a group of mice with a mouse diet and the other with a diet rich in fat and cholesterol. After eight weeks, the mice with the fat diet started to lose hair, the hair got white and there were lesions on their skin.

Subroto Chatterjee is one of the researchers at the Johns Hopkins, concluding that:

“Our findings show that a Western diet causes hair loss, hair whitening and skin inflammation in mice, and we believe a similar process occurs in men who lose hair and experience hair whitening when they eat a diet high in fat and cholesterol.”

The D-PDMP molecule previously created was administered to the mice that suffered hair loss and other symptoms. The results were incredible and they symptoms quickly disappeared: hair started to grow back, the color went back to normal and the inflammation of the skin was reduced.

The experimental drug decreased the level of a type of white blood cells – neutrophils, which are linked to skin inflammation and problems of wound healing. The fat diet made the skin get wrinkly because it reduces the level of ceramides in the skin. The D-PDMP treatment returned the ceramide levels back to normal.

Treating Hair Loss and Skin Diseases

The next step would be to prove this effect works in human trials.

Chatterjee hopes that the research will continue and see if D-PDMP is safe for humans or if they can replicate these results in humans. It’s an important step in fighting against hair loss and improving wound healing in humans, concludes Chatterjee:

“Further research is needed, but our findings show promise for someday using the drug we developed for skin diseases such as psoriasis, and wounds resulting from diabetes or plastic surgery.”


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