Resistance to antibiotics could have a cure. Infectious disease doctors, drug experts, microbiologists, and biochemists have all teamed up for the latest study that shows antibiotics are not always mandatory in order to cure sepsis.
The test was conducted on mice, but it was nonetheless successful.
Instead of killing bacteria with antibiotics, researchers treated infected mice with molecules that were blocking toxin formation in bacteria.
Each and every mouse that was treated survived. The breakthrough study has been published in Scientific Reports, and it suggests that infections in humans might be cured the very same way.
Treating mice with these therapeutic molecules was able to cure infections caused by methicillin-resistant Staphylococcus aureus (MRSA).
S. aureus is highly known for its ability to overcome even the most potent antibiotics.
In mice, the treatment with small molecules resulted in 100% survival, and 70% of the untreated animals died.
A potential solution to the global threat of antibiotic resistance
The small molecules have been as effective in promoting survival as antibiotics that are currently used to treat the infections.
It also seems that the molecules were able to give the antibiotics a boost, enhancing their effect.
“For relatively healthy patients, such as athletes suffering from a MRSA infection, these molecules may be enough to clear an infection,” said Menachem Shoham, senior author on the study.
He continued and explained that “For immunocompromised patients, combination therapy with the molecules and a low-dose antibiotic may be in order. The antibiotic in the combination could be one to which the bacteria are resistant in monotherapy because our small molecules enhance the activity of conventional antibiotics, such as penicillin.”
Iy also seems that having support from the small molecules, previously obsolete antibiotics could reenter the clinic.
The study and its results could turn out to be a partial solution to the global threat of antibiotic resistance which would be a highly significant finding.
Rada attended the courses in the Faculty of Letters, Romanian-English section, and finished the Faculty of Theatre and Television, Theatrical Journalism section, both within the framework of Babeş-Bolyai University of Cluj-Napoca. Up ’til now, she reviewed books, movies, and theatre-plays, enjoying subjects from the cultural niche. Her experience in writing also intersects the IT niche, given the fact that she worked as a content editor for firms that produce software for mobile devices. She is collaborating with online advertising agencies, writing articles for several websites and blogs.